Fri Feb 14 2025

37 articles - From Friday Feb 07 2025 to Friday Feb 14 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Inflamm Bowel Dis

Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference.

The group focused on key issues, such as stool donation, donor selection, characterization of fecal biomass, potential administration routes, as well as the process of induction, maintenance, and endpoint readouts. The consensus achieved during this conference established standardization of methods and protocols to enhance the current quality of research, with the aim of eventual implementation of FMT in managing UC and the ultimate goal of improving patient outcomes.

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Meta-analysis

meta-analyses and systematic reviews

Pancreas

Pancreatic Cystic Lesions in Children: A Comprehensive Scoping Review.

We present a comprehensive review and evidence-based management recommendations with management algorithms for pediatric pancreatic cystic lesions. Given the rarity of many of these entities, this review also highlights many aspects of PPCL, which are not adequately described in the current literature.

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Performance of Clinical Risk Prediction Models for Post-ERCP Pancreatitis: A Systematic Review.

The use of PEP prediction tools can support the management of patients following ERCP. Implementation studies assessing the optimal usability of these tools, followed by prospective evaluations, are needed to evaluate their potential impacts on reducing PEP in real-world practice.

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Systematic Review of Volume and Methodological Quality of Randomized Trials in Acute Pancreatitis.

The quantity and quality of published RCTs relating AP management has increased over time, however significant shortcomings of methodological quality persist. Significant improvements in the conduct and reporting of randomized trials in AP are required to improve the evidence base in this field.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Adipose tissue content of n-6 polyunsaturated fatty acids and all-cause mortality: a Danish prospective cohort study.

Adipose tissue content of linoleic acid was inversely associated with all-cause mortality, whereas adipose tissue content of arachidonic acid was associated with a higher all-cause mortality.

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Diet and survival after a diagnosis of ovarian cancer: a pooled analysis from the Ovarian Cancer Association Consortium.

Adherence to a more heathy, less inflammatory diet may confer a survival benefit for individuals with early-stage ovarian cancer.

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Effect of kangaroo mother care in low birth weight infants on human milk intake: a randomized controlled trial.

There were no evidence of any effect of KMC on the concentration of several human milk components. CTRI/2017/04/008430, Clinical Trials Registry - India.

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Folic acid supplementation in children with sickle cell disease: A randomized double-blind non-inferiority crossover trial.

Despite mandatory food fortification and advances in the medical treatment of sickle cell disease, it appears that some children with this condition may still benefit from daily folic acid supplementation. Whether this translates to improved clinical outcomes remains uncertain. as NCT04011345 (

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Impact of Formula Protein Quantity and Source on Infant Metabolism: Serum, Urine and Fecal Metabolomes of a Randomized Controlled Study.

Comprehensive metabolomics profiling of serum, urine and feces captures molecular-level changes and informs potential strategies for formula optimization. Both the quantity and source of protein significantly influenced the metabolic profiles of formula-fed infants. However, modifications in protein alone cannot fully resolve the metabolic differences between formula-fed and human milk-fed infants, highlighting the complexity of mimicking the human milk feeding-associated metabolic profile. Clinical trial registration

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Impact of linear growth-improving interventions on childhood overnutrition at 24 months: a randomized controlled trial.

Comprehensive interventions from preconception to early childhood improve linear growth but do not result in overweight and/or obesity at 24 mo. With better resultant linear and ponderal growth, they converge with the World Health Organization's "double-duty actions for nutrition" for LMIC settings, where childhood overweight and/or obesity is a growing concern.

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Inflamm Bowel Dis

A Role for Leucine-Rich α2-Glycoprotein in Leukocyte Trafficking and Mucosal Inflammation in Inflammatory Bowel Disease.

Our data suggest that LRG accelerates the progression of colonic inflammation at least in part by enhancing leukocyte trafficking through the upregulation of TGF-β1-induced endoglin expression in vascular endothelial cells.

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MK2 Inhibition in CD4+ T Cells Protects Against IFNγ and IL-17A, Chronic Inflammation, and Fibrosis in Inflammatory Bowel Disease Models.

The MK2 pathway regulates inflammatory CD4+ T cells and fibrosis in IBD models and is a potential therapeutic target.

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Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis.

Our results highlight the involvement of metabolic pathways and mitochondrial homeostasis in determining treatment response and their ability to provide promising classification signals with detection levels in both the colon and the bloodstream.

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Winnie Mice: A Chronic and Progressive Model of Ulcerative Colitis.

While Winnie mice are currently less studied compared to other more established models of colitis, much has been discovered in the initial years of its use as a UC-like model. In summary, the use of Winnie mice adds to the growing armamentarium that is required to develop precision-based medicine for its future application in treating complex multifactorial diseases, such as UC.

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J Crohns Colitis

A transcriptomic score to classify the inflammation-dysplasia-cancer sequence lesions in Inflammatory Bowel Disease.

We identified a tissue-based transcriptomic score to classify IDC lesions in IBD patients and uncovered some of the pivotal genes in the carcinogenesis related to inflammation in IBD.

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Adverse maternal outcomes after vaginal versus caesarean delivery in women with Crohn's disease and prior perianal surgery: A population-based study.

Women who delivered vaginally versus by c-section had less new perianal surgery (aOR 0.47, 95% CI 0.24-0.93) and no significant differences in intestinal CD surgery (aOR 0.87, 95% CI 0.43-1.75), hospital diagnosed infection (aOR 0.50, 95% CI 0.18-1.38), outpatient antibiotic prescription (aOR 0.92, 95% CI 0.65-1.28) or major hemorrhage (aOR 0.79, 95% CI 0.39-1.59). Vaginal delivery was not associated with increased important adverse maternal outcomes in mothers with CD and prior perianal surgery.

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Prevalence, incidence and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models.

IBD cases can be accurately identified using administrative data. The prevalence of IBD in the Netherlands is increasing slower than expected, suggesting a trend towards the epidemiological stage of Prevalence Equilibrium.

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Liver Transpl

Association of perfusate cytokine concentrations during liver graft ex-situ normothermic perfusion to donor type and postoperative outcomes.

This is the first study to compare cytokines profile during NMP in three different types of donors and correlate it to clinical outcomes. A correlation between IL-6 concentration and graft failure was found. The role and the significate of inflammatory markers in MP perfusate and their potential to assess graft viability and the risk of post-LT complications has to be further addressed.

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Pancreas

Analysis of the Application of Laparoscopic Peritoneal Lavage and Drainage in the Early Treatment of Severe Acute Pancreatitis.

In patients with SAP complicated by ascites, early-stage LPLD can effectively alleviate systemic inflammatory response, expedite organ failure reversal, delay disease progression, avoid step-up treatment, reduce postoperative complications and shorten hospitalization duration. This minimally invasive therapeutic approach represents a promising strategy for early intervention in SAP.

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From Acute Pancreatitis to Diabetes: Risk Factors and Timeline Analysis in a Pediatric Population Study.

Children face DM risks during or after AP episodes. Enhanced DM screening and close outpatient follow-up within 3 to 6 months post-discharge are recommended.

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Impact of Statin Use on Survival in Patients With Unresectable Pancreatic cancer Receiving Gemcitabine Plus Nab-Paclitaxel: A Multicenter Retrospective Study.

PFS and OS did not significantly differ by liposolubility of statins, either. Stain use was not associated with PFS or OS in patients with unresectable PC receiving GnP.

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International Classification of Diseases, Tenth Revision Diagnosis Codes Are Overutilized in the Diagnosis of Chronic Pancreatitis.

Of note, 81 patients had no identifiable abdominal pathology. Although the OneFlorida database makes multicenter research more accessible, it does not replace labor-intensive chart review given the propensity for overdiagnosis.

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Markers of Collagen Formation and Degradation in Serum and Pancreatic Fluid Collections in Patients With Acute and Chronic Pancreatitis.

The high serum levels in patients suggest increased overall fibrotic activity in pancreatitis patients as compared to healthy controls. PRO-C3 elicited higher levels in the pancreatic fluid, indicating localized fibrotic activity.

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Serum Exosomal miR-216a Contributes to Acute Pancreatitis-Associated Acute Lung Injury by Enhancing Endothelial cell Vascular Permeability via Downregulating LAMC1.

In summary, serum exosomal miR-216a can promote the onset and progression of AP-ALI by augmenting endothelial cell vascular permeability. This finding presents a theoretical basis for exploring new therapeutic approaches targeting AP-ALI.

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The Predictive Value of Red Cell Distribution Width for the Risk of Sepsis in Patients with Acute Pancreatitis: A Retrospective Cohort Study.

Delong test showed that the area under the curve (AUC) of SOFA+RDW, SAPSII+RDW and BISAP+RDW scoring models were significantly greater than those of SOFA, SAPSII and BISAP scoring models, respectively (0.822 vs 0.776; 0.708 vs 0.688; 0.609 vs 0.550, respectively). RDW is not only linked to sepsis risk, but also has a certain additive effect on SOFA, SAPSII and BISAP models, among which SOFA+RDW has the highest discrimination capacity for sepsis in AP patients.

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Usefulness of MRI T1 Mapping in Predicting Postoperative Pancreatic Fistula After Distal Pancreatectomy.

High R1 values at the pancreatic transection site indicate a higher possibility of developing grade B/C POPF. Preoperative MRI T1 mapping may be valuable for predicting POPF after DP.

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Usefulness of Semiautomated 3D Volumetric Assessment of Liver Tumor Burden for Patients With Unresectable Pancreatic Neuroendocrine Tumor: A Pilot Study.

Progression-free survival was significantly longer in patients in the 'equal group' than the 'overestimated group' (981 vs 366 days, P < 0.01). This pilot study revealed a good correlation between visual and volumetric assessments, and visual assessment overestimated LTB, compared to volumetric assessment.

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Vascular Complications in Patients With Pancreatic Walled-Off Necrosis-A Retrospective, Single Cohort Study.

Vascular complications are common in WON patients, but only bleeding is associated with increased morbidity and in-hospital mortality. Most SVT occur before an index intervention, while bleeding episodes primarily occur afterwards.

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Pancreatology

The efficacy and safety profile of third-line treatment in patients with metastatic pancreatic adenocarcinoma.

In real-world settings, patients with mPDAC receiving third-line chemotherapy may have a moderate survival advantage, although clinicians should carefully select patients owing to high incidence of grade ¾ toxicities.

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Why is the rectal route for NSAIDS favorable for preventing post-ERCP pancreatitis?

Our findings suggest that the efficacy of rectal diclofenac in PEP prevention relates more to its higher and consistent systemic exposure than its absolute pancreas levels. The implications are that the rectal route provides both systemic and pancreas exposure for the full duration of PEP vulnerability.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Letter to the Editor: Microscopic Colitis after Ocrelizumab for Multiple Sclerosis.

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J Crohns Colitis

Disease-Modifying Anti-Inflammatory Drugs: Shaping the Future of Inflammatory Bowel Disease Care.

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Liver Transpl

Recurrent HCC after liver transplantation: Small steps, while awaiting a breakthrough.

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Pancreas

Assessment of Medical Pancreatology Fellowship Training in the United States: A Collaborative Alliance for Pancreatic Education and Research (CAPER) Initiative.

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Pancreatic Malformation and Heterotaxy Syndrome Associated With 6q25.1 Haploinsufficiency.

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Thrombophilia as a Novel Cause of Acute Pancreatitis: A Case Report.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Albumin ratio-based indicator for predicting inpatient mortality in acute pancreatitis patients admitted to the intensive care unit.

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